Virology

1973

Nagoya University School of Medicine, M. D.

1978

Nagoya University, Graduate School of Medicine, Ph. D.

1978

Research Associate, Nagoya University School of Medicine.

1978

Postdoctoral fellow, The Pennsylvania State University, Hershey, USA

1982

Associate Professor, Research institute for Disease Mechanism and Control, Nagoya University School of Medicine

1994

Professor, Laboratory of Virology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine

2000

Professor, Department of Virology, Nagoya University Graduate School of Medicine.

Development of novel oncolytic HSV and vaccine against viral infections

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1. Yamauchi Y et al. Herpes simplex virus induces extensive modification and dynamic relocalisation of the nuclear mitotic apparatus protein (NuMA) in interphase cells. J Cell Sci 15: 2087-2096 (2008)
2. Kato A et al. Identification of a physiological phosphorylation site of the Herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells. J Virol 82: 6172-6189 (2008)
3. Ushijima Y et al. Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin Ligase Nedd4 and Increases its Ubiquitination. J Virol 82: 5220-5233 (2008)
4. Kamakura M et al. Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants. Microb Infect 10: 405-413 (2008)
5. Yamauchi Y et al. The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1) is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids. J Virol 82: 1094-1106 (2008)
6. Kohno S et al. Oncolytic Virotherapy with an HSV amplicon vector expressing granulocyte-macrophage colony-stimulating factor using the replication-competent HSV type I mutant HF10 as a helper virus. Cancer Gene Ther 14: 918-926 (2007)
7. Kasuya H et al. Suitability of a US3-inactivated HSV mutant (L1BR1) as an oncolytic-virus for pancreatic cancer therpay. Cancer Gene Ther 14: 533-542 (2007)
8. Kimata H et al. Pilot study of oncolytic viral therapy using mutant herpes simplex virus HF10 against recurrent metastatic breast cancer. Ann Surg Oncol 13: 1078-1084 (2006)
9. Kato A et al. Herpes simplex virus 1-encoded protein kinase UL13 phosphorylates the viral US3 protein kinase and regulates nuclear localization of viral envelopment factors UL34 and UL31. J Virol. 80: 1476-1486 (2006)
10. Nozawa N et al. Herpes simplex virus type 1 UL51 protein is involved in maturation and egress of virus particles. J Virol 79: 6947-6956 (2005)
11. Kato A et al. Identification of proteins phosphorylated directly by the US3 protein kinase encoded by herpes simplex virus 1. J Virol 79: 9325-9331 (2005)
12. Kudoh A et al. Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein Barr virus immediate early and early genes, preventing viral lytic replication. J Virol 78:104-115 (2004)
13. Nishiyama Y et al. Herpes simplex virus gene products: the accessories reflect her lifestyle well. Rev Med Virol 14: 33-46 (2004)
14. Kanamori M et al. Epstein-Barr virus nuclear antigen leader protein induces expression of thymus and activation-regulated chemokine in B cells. J Virol 78: 3984-3993 (2004)
15. Nishimura H et al. Intraepithelial γδ T may bridge a gap between innate and acquired immunity to herpes simplex virus type 2. J Virol 78: 4927-4930 (2004)
16. Kawaguchi Y et al. Conserved protein kinases encoded by herpesviruses and a cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1δ. J Virol 77: 2359-2368 (2003)
17. Nozawa N et al. Subcellular localization of UL51 protein of herpes simplex virus type 1 and role of palmitoylation in Golgi targeting. J Virol 77: 3204-3216 (2003)
18. Ihira M et al. Variation of human herpesvirus 7 shedding in saliva. J Infect Dis 188: 1352-1354 (2003)
19. Yoshikawa T et al. Human herpesvirus 6 viremia in bone marrow transplant recipients:clinical features and risk factors. J Infect Dis 185: 847-853 (2002)
20. Koshizuka T et al. Identification and characterization of the UL56 gene product of herpes simplex virus type 2. J Virol 76: 6718-6728 (2002)
21. Yamauchi Y et al. Herpes simplex virus type 2 UL14 gene product has heat shock protein (HSP)-like functions. J Cell Sci 115: 2517-2527 (2002)
22. Nishiyama Y et al. Antiapoptotic protein kinase of herpes simplex virus. Trend Microbiol 10:105-107 (2002)

Kojima Saburo Memorial Award for Distinguished Research on Infectious Diseases (2006).
Mochida Memorial Award for Medicine and Pharmaceutical Research (2006).